15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners

ABSTRACT

This disclosure describes esters having prostaglandin-like activity of 15-deoxy-16-hydroxy-16-substituted-prostanoic acids formed by replacing the hydroxy group of the C 1  -carboxylic acid substituent with para-acetamidophenoxy, methylsulfonylamido, para-acetylphenoxy, para-phenylphenoxy, C 3  -C 10  cycloalkoxy, arylalkoxy wherein the alkoxy group has from 7-12 carbon atoms, phenoxy or phenoxy substituted with 1-3 chlorine atoms or C 1  -C 3  alkyl, phenacyloxy or phenacyloxy ring-substituted with from 1-3 bromine atoms, a nitro moiety, C 1-C   8  arylalkyl, or arylalkoxy wherein the alkoxy group has from 7-12 carbon atoms; substituted arylamino (C 1  -C 12 ), substituted-naphthoxy, fluorenoxy, carboxyalkoxy (C 5  -C 11 ), 5-indanyloxy, benzoylphenoxy, benzyloxy or ring-substituted benzyloxy, glyceryloxy, phosphatoglyceryloxy, amino substituted with an alkanoyl or cycloalkanoyl group; aroyl or substituted aroyl; alkylsulfonyl; arylsulfonyl or substituted-arylsulfonyl, hydrazinyl and substituted hydrazinyl; alkylamino (C 1  -C 5 ), or the semicarbazide of the para-formylphenoxy group.



